The Ultimate Complete Guide to Rick Simpson Oil (RSO): Everything You Need to Know in 2025
Rick Simpson Oil (RSO) is a highly concentrated, full-spectrum cannabis extract that has captured widespread attention for its potency and potential therapeutic applications. This comprehensive guide covers everything from its origins to the complete 90-day treatment protocol.
Rick Simpson Oil (RSO) is a highly concentrated, full-spectrum cannabis extract that has captured widespread attention for its potency and potential therapeutic applications. Named after its creator, Canadian activist Rick Simpson, RSO is often described as a thick, tar-like substance rich in cannabinoids, primarily THC, along with CBD, terpenes, flavonoids, and other plant compounds.
Unlike milder cannabis products such as tinctures or standard edibles, RSO delivers a powerful, full-extract experience that retains the plant's natural profile for what many describe as an "entourage effect," where compounds work synergistically to enhance benefits.
Important Disclaimer
While anecdotal reports and emerging research highlight potential benefits, RSO is not FDA-approved, and scientific evidence for many claims remains limited. Always consult a healthcare professional, especially if you have health issues or take medications, as THC can cause interactions.
History and Background of RSO
The story of RSO begins with Rick Simpson, a former Canadian engineer turned cannabis advocate. In 1997, Simpson suffered a workplace accident that led to chronic headaches, tinnitus, and other symptoms. He found relief through cannabis and began researching its medical potential.
In 2003, after being diagnosed with basal cell carcinoma (a form of skin cancer), Simpson developed a concentrated oil by extracting cannabinoids from cannabis using solvents. He applied it topically to his lesions, claiming it cured his cancer within days. Inspired, Simpson shared his recipe freely through his website (phoenixtears.ca) and his book, *Phoenix Tears: The Rick Simpson Story*, but never commercialized it.
Rick Simpson's Journey
- 1997: Workplace accident leads to chronic symptoms
- 2003: Diagnosed with skin cancer, develops concentrated cannabis oil
- 2009: Flees to Europe after legal challenges in Canada
- 2025: Legacy continues with RSO available in legal dispensaries
Facing legal challenges in Canada for distributing cannabis oil, Simpson fled to Europe in 2009, where he continues advocating for RSO's use in treating serious illnesses like cancer, chronic pain, and more. While his personal anecdotes have inspired thousands—leading to widespread home production and use—medical experts caution that these claims lack robust clinical trials.
What Is RSO? Composition and Key Differences
At its core, RSO is a full-spectrum extract made from indica-dominant cannabis strains, chosen for their sedative properties. It's dark, viscous, and sticky, with THC levels often ranging from 50-90%, alongside varying amounts of CBD (typically lower) and other minor cannabinoids like CBG or CBN.
What Sets RSO Apart?
Vs. CBD Oil
CBD oils are non-intoxicating, with <0.3% THC, focusing on wellness like anxiety relief. RSO is psychoactive and THC-dominant, aimed at more intense needs.
Vs. Distillate
Distillates are ultra-refined for nearly pure THC (up to 99%), stripping away terpenes. RSO is unrefined, preserving the plant's full entourage for broader effects.
Vs. FECO
Similar to RSO but often ethanol-based, FECO may retain more natural flavors and is sometimes considered a "cleaner" alternative.
Legal Status of RSO in 2025
Federally in the U.S., RSO remains illegal under Schedule I due to high THC, but state laws vary. As of December 2025, recreational cannabis is legal in 24 states (e.g., California, Colorado, New York), and medical use in 38, allowing RSO purchases at dispensaries with a card or for adult use.
United States
Legal in 24 recreational states and 38 medical states. Always verify local regulations.
Canada
RSO permitted with prescriptions through licensed producers.
Europe
Growing acceptance in Germany, Netherlands, and other countries for medical use.
Other Regions
Israel, Australia, and parts of South America have varying levels of access.
Always opt for lab-tested products to ensure safety from contaminants like pesticides or heavy metals. Possession or production in non-legal areas can result in penalties.
Safety Notes Before You Begin
Safety is non-negotiable with RSO's strength:
Potency and Variability
Effects depend on strain, your tolerance, metabolism, and method—start low to avoid overwhelm.
Medical Guidance
Consult a clinician, especially if pregnant, on medications (e.g., blood thinners, antidepressants), or with conditions like heart disease or psychiatric issues. THC can amplify sedatives or interact with chemo drugs.
Quality and Legality
Use lab-tested sources; avoid DIY if inexperienced. No driving or operating machinery while impaired.
General Warnings
Not for pets (toxic); keep away from children. If overconsumed, symptoms like anxiety pass but seek help if severe.
Forms of RSO: Syringe, Capsules, Edibles, Suppositories, and Tincture
RSO comes in various forms for convenience and targeted use:
Syringe
The most common, allowing precise dosing (e.g., 1ml markings). Ideal for oral or topical; airtight for storage.
Capsules
RSO filled into gel caps for discreet, tasteless ingestion. Great for consistent dosing without the bitter taste.
Edibles
Mix RSO into foods like butter, chocolate, or gummies. Heat gently to avoid degrading THC; effects are long-lasting but onset delayed.
Suppositories
For rectal/vaginal use, bypassing the liver for faster, non-psychoactive relief (e.g., for pain or nausea). Common in medical protocols.
Tincture
Dilute RSO in alcohol or carrier oil for a sublingual dropper form. This makes it easier to dose and absorb quickly.
How to Use RSO
Versatile methods suit different goals:
Oral Ingestion/Swallowing
Swallow directly or in edibles/capsules. Onset: 1-2 hours; Duration: 4-8+ hours. Pair with fats for better absorption.
Sublingual
Under tongue for 60-90 seconds. Faster onset: 15-30 minutes; good for quick relief.
Topical
Apply to skin for localized effects (no high). Useful for pain or skin issues.
Suppositories
Insert for systemic but non-intoxicating benefits.
Practical Tips
- Use syringes for accuracy
- Start at night to assess tolerance
- Hydrate and eat fatty foods with doses
- Avoid vaping/smoking due to thickness and residues
Effects, Benefits, and Conditions RSO May Treat
Positive Effects
- Deep relaxation
- Pain relief
- Anti-inflammation
- Appetite boost
- Nausea reduction
- Improved sleep
Potential Side Effects
- Psychoactive high
- Paranoia or anxiety
- Dizziness
- Dry mouth
- Increased heart rate
Conditions People Use RSO For (Anecdotally)
- •Cancer symptoms (e.g., chemo nausea)
- •Chronic pain
- •Epilepsy
- •Multiple sclerosis
- •Arthritis
- •Asthma
- •Depression
- •High blood pressure
- •Insomnia
- •Addiction recovery
Important: Lab studies suggest anti-tumor properties, but human evidence is inconclusive—RSO is not a cure. As of 2025, it's valued primarily for palliative care and symptom management.
Beginner Dosing Strategy and Building Tolerance
Start Low, Go Slow
Day 1-3
Start with half a rice grain (2-5mg THC) once daily at night.
Day 4-7
If comfortable, increase to a full rice grain. Hold for 2-3 days before increasing.
Week 2+
Gradually increase based on tolerance. Most people settle at 100-300mg per day.
Factors Affecting Dosage
- Body weight and metabolism
- Previous cannabis tolerance
- Severity of condition being treated
- Method of consumption (oral vs sublingual vs suppository)
Full 90-Day RSO Schedule (Treatment Protocol)
Inspired by Rick Simpson's regimen for serious conditions (60g over 90 days):
Phase 1: Days 1-14 – Tolerance Building
Dosage: Half rice grain nightly
Goal: Tolerance test - assess your body's reaction with minimal psychoactive effects. Start very small to avoid overwhelm.
Phase 2: Days 15-30 – Gradual Increase
Dosage: Full grain nightly; optional half grain morning
Goal: Slowly increase dosage while monitoring effects. You may begin to feel more pronounced effects.
Phase 3: Days 31-60 – Therapeutic Dose
Dosage: Half grain morning, full grain evening
Goal: Maintain consistent blood levels. Monitor consistency and adjust if side effects become uncomfortable.
Phase 4: Days 61-90 – Maintenance & Reassessment
Dosage: 1-2 grains daily, split doses
Goal: Maintain therapeutic dose. Reassess with healthcare provider to determine if protocol should continue, adjust, or stop.
Important Notes:
- • Adjust for side effects; journal everything
- • Not medically proven—combine with conventional medical care
- • Always consult with a healthcare professional before starting
- • Some patients never reach the full 1g/day dose and find relief at lower amounts
Storage, Quality, and Safety
Proper Storage
- Store in airtight syringes/capsules
- Keep in cool, dark places
- Refrigerator okay (warm before use)
- Label with potency and date
Quality Indicators
- Shelf life: 1-2 years when stored properly
- Bad signs: Mold, off smells, separation
- Good color: Dark brown to black (natural)
Where to Buy or Obtain RSO
In legal areas, purchase from licensed dispensaries. Typical cost: $30-60 per gram. Always ensure products come with lab tests (Certificate of Analysis).
Shop Our Lab-Tested RSO Products
We offer authentic, lab-tested Rick Simpson Oil in syringes, capsules, and other formats. All products come with current COAs and discreet shipping.
Browse RSO ProductsAlternatives to RSO
CBD Oils
Non-intoxicating option for wellness and anxiety relief without the high.
Tinctures & Edibles
Milder options for those who want the benefits without the intensity of RSO.
Quick FAQs
Can I vape RSO?
No—too thick and contains residuals that aren't safe for inhalation.
How long until RSO kicks in?
Oral: 1-2 hours. Sublingual: 15-30 minutes.
What if I take too much?
Reduce dose immediately. Use CBD to counteract THC. Symptoms are uncomfortable but not fatal. Seek help if severe.
Is RSO safe for pets?
No—THC is toxic to pets. Never give RSO to animals.
Does RSO cure cancer?
There is no scientific evidence that RSO cures cancer. While some preclinical studies show anti-tumor properties in lab settings, human clinical trials are lacking. RSO is valued for symptom management and palliative care, not as a cure.
Putting It All Together: Final Thoughts
Rick Simpson Oil represents a powerful approach to cannabis medicine, offering high concentrations of cannabinoids for those seeking relief from serious conditions. While Rick Simpson's story has inspired thousands, it's crucial to approach RSO with realistic expectations, medical guidance, and respect for its potency.
Whether you're exploring RSO for chronic pain, cancer symptom management, or other conditions, always start low, go slow, and work with healthcare professionals. The 90-day protocol provides a structured approach, but individual needs vary greatly.
As cannabis legalization expands and research continues, we're learning more about RSO's potential and limitations. In 2025, many medical professionals now recommend FECO as a cleaner alternative, but RSO remains a popular choice for those seeking the original formula.
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